Control of behavioral flexibility by the lateral habenula
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولOngoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats
The lateral habenula (LHb) plays a role in a wide variety of behaviors ranging from maternal care, to sleep, to various forms of cognition. One prominent theory with ample supporting evidence is that the LHb serves to relay basal ganglia and limbic signals about negative outcomes to midbrain monoaminergic systems. This makes it likely that the LHb is critically involved in behavioral flexibilit...
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There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studie...
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Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of de...
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Reward is crucial for survival of animals and influences animal behaviours. For example, an approaching behaviour to reward is more frequently and quickly elicited when a big reward is expected than when a small reward is expected. Midbrain dopamine neurons are thought to be crucial for such reward-based control of motor behaviour. Indeed, dopamine neurons are excited by cues predicting reward ...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2017
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2017.07.012